Urinary Excretion of Cyclic AMP by Cold-Acclimated Rats
- 1 May 1974
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 52 (5) , 414-417
- https://doi.org/10.1139/o74-061
Abstract
Cold-acclimated rats living in the cold (4°) excrete more cyclic AMP in their urine than do control warm-acclimated rats living at room temperature (26°–28°). However, cold-acclimated rats, returned to the cold after a few days at room temperature and presumably raising their metabolic rate by nonshivering thermogenesis in response to the noradrenaline and adrenaline secreted by the sympathetic nervous system, excrete the same amount of cyclic AMP in their urine as do warm-acclimated rats of the same age put into the cold for the first time and presumably raising their metabolic rate by shivering. Thus, no evidence could be found for an altered utilization of the adenyl cyclase system in the cold-acclimated rat. This, together with previous findings of unaltered levels and properties of noradrenaline-stimulated adenyl cyclase in brown adipose tissue and skeletal muscle of cold-acclimated rats, leads us to the conclusion that the enhancement of the metabolic response to noradrenaline in cold-acclimated rats is not due to any alteration in the adenyl cyclase system.Keywords
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