Augmentin: Laboratory Studies

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Abstract
Clavulanic acid is a β-lactam antibiotic which, although it has little intrinsic activity, is a potent inhibitor of bacterial β-lactamases. When combined with amoxycillin its range of activity includes penicillinase-producing strains of Staphylococcus aureus and many of the β-lactamase-producing strains of Gram-negative bacilli. Bacteria sensitive to augmentin include amoxycillin-resistant strains of Haemophilus influenzae and Escherichia coli, in addition strains of Klebsiella aerogenes, Proteus mirabilis, Proteus vulgaris and Bacteroides fragilis are usually sensitive. The β-lactamases produced by Enterobacter spp, Proteus morgani, Serratia marcescens and Pseudomonas aeruginosa are less susceptible to clavulanic acid and these bacteria are usually resistant to augmentin (1).

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