BLOOD PHENOL LEVEL AFTER TOPICAL APPLICATION OF PHENOL-CONTAINING PREPARATIONS

6 June 1953

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 152 (6) , 506-509
https://doi.org/10.1001/jama.1953.03690060022008

Abstract

Calamine lotion, containing 1 or 2% phenol, and a preparation composed of phenol (4.75%) and camphor (10.86%) in aromatized liquid petrolatum¹ (camphophenique^®) have been favorites for several decades for the treatment of disorders of the skin. Both preparations have been applied extensively with only a single incident of harmful effect reported for each. This is in contrast to the local changes, such as gangrene, and systemic effects that resulted frequently from application of aqueous solutions containing similar concentrations of phenol. Recently a fatality occurred because of the indiscriminate application of large volumes of a proprietary preparation containing 2.3% phenol in corn oil (foille^®). This material was applied to a dressing covering 25 or 30% of a boy's body surface for the treatment of a kerosene burn.¹ The object of this investigation was to follow the level of "free" and of "conjugated" phenol of the blood after

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