Immunoprofile of Reactions in Leprosy

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Abstract
The immunologic profile during erythema nodosum leprosum (ENL) revealed increased percentage and absolute count of B‐lymphocytes, in addition to considerably lowered levels of complement component C3. Serum immunoglobulins—IgG, IgA, and IgM—were significantly raised after subsidence of ENL, whereas upgrading reaction showed an increase of absolute count of total T lymphocytes and percentage and count of B‐lymphocytes. In addition, a raised serum IgM level was noted after regression of ENL. Downgrading reaction demonstrated a decreased percentage of early T‐lymphocytes and raised the absolute count of B‐lymphocytes. Serum IgA levels were found to be increased after amelioration of ENL.