Urinary Excretion Studies Following the Administration of Pteroic Acid

Publisher Website
Google Scholar
Abstract
Pteroic acid was administered to normal adult human [male][male] and the urine was assayed for "folic acid" with Streptococcus faecalis R and for pteroylglutamic acid with Lactobacillus casei. On the basis of the relative response of these organisms to pteroic acid and pteroylglutamic acid, the apparent concn. of these compounds in the urine was detd. The oral admn. of from 2-10 mg. of pteroic acid resulted in only a very small amt. of urinary pteroic acid. Following the intraven. admn. of 2 mg. of pteroic acid, the microbiologic assays of the urine indicated that from 15-46% of the compound was excreted as pteroic acid and that only about 1% appeared to be converted to pteroylglutamic acid. The excretion studies indicated that only a small proportion of an administered dose of pteroic acid was converted to pteroylglutamic acid and that pteroic acid is poorly absorbed from the gastrointestinal tract.
Keywords