Intestinal Metabolism of DNOC and DNBP in the Rat
- 1 May 1980
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 46 (5) , 326-328
- https://doi.org/10.1111/j.1600-0773.1980.tb02462.x
Abstract
The metabolism of the dinitrophenols DNOC and DNBP [herbicides] and their respective monoamino derivatives, 6-ANOC [2-methyl-4-nitro-6-aminophenol] and 6-ANBP [2-(1-methyl-n-propyl)-4-nitro-6-aminophenol], was studied in rat cecal incubates. All the compounds were reduced to their corresponding diamino metabolites. The results are discussed in relation to the comparative toxicology of the dinitrophenols with special regard to a possible significance of the intestinal metabolites.Keywords
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