Experimental Studies on the Specificity of Skin Tests for the Diagnosis of Schistosomiasis

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Abstract
Rabbits were repeatedly exposed to 3 spp. of non-human schistosome cercariae, C. stagnicolae, C. physellae and C. elvae. with the production, after the first exposure, of an extensive dermatitis. Approx. 7 weeks after the last exposure, intradermal tests were performed\on the 5 exptl. and 2 control rabbits, using antigens made from the 3 non-human schistosome cercariae, 2 different antigens prepared from cercariae of Schistosoma mansoni. and an antigen made from cercariae of a strigeid, Diplostomum flexicaudum. Essentially negative reactions were obtained from the 2 Schistosoma mansoni antigens when employed in high dilutions. The results obtained with the other two antigens were equivocal. An effective method for the concn. of living dermatitis-producing schistosome cercariae was developed by utilizing the positive phototropic and negative geotropic reactions of the cercariae.

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