Naja haje haje (Egyptian cobra) Venom

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Abstract
Three toxins (CM-2, CM-11 and CM-12) were purified from N. haje haje venom. Whereas toxin CM-11 contains 65 amino acid residues and 5 intrachain disulfide bridges, toxin CM-2 and CM-12 comprise, respectively, 61 and 62 residues; both contain 4 disulfide bridges. The complete primary structures of the 3 toxins were established. The sequence and the invariant amino acid residues of CM-2 resemble those of part of a long neurotoxin, a short neurotoxin and a cytotoxin. The sequence of CM-11 reveals that it is a homolog of the neurotoxins and to some extent also a cytotoxin. The immunochemical properties and the sequence of CM-12 suggest that it is related to the cytotoxin group. The sequence of CM-11 and CM-12 from N. haje haje venom show a high degree of homology with those of the corresponding toxins isolated from N. haje annulifera or N. melanoleuca venoms.

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