Gossypol binds to a high‐affinity binding site on human serum albumin
- 27 June 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 157 (1) , 28-30
- https://doi.org/10.1016/0014-5793(83)81109-0
Abstract
The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathione S-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.Keywords
This publication has 8 references indexed in Scilit:
- Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruziScience, 1982
- Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agentAmerican Journal of Obstetrics and Gynecology, 1982
- Purification and bilirubin binding properties of glutathione S -transferase from human placentaFEBS Letters, 1981
- Bilirubin binding to human liver ligandin (glutathione S-transferase).Journal of Biological Chemistry, 1980
- The First Clinical Trial of Gossypol on Male AntifertilityPublished by Springer Nature ,1980
- Bilirubin: Worked Out Years Ago?Pediatrics, 1979
- Competitive Binding of Bilirubin and Drugs to Human Serum Albumin Studied by Enzymatic OxidationJournal of Clinical Investigation, 1974
- Urinary and Biliary Excretion of 14C-Gossypol in SwineJournal of Nutrition, 1974