Does the HIV Nef protein mimic the MHC?
- 12 November 1993
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 333 (3) , 211-213
- https://doi.org/10.1016/0014-5793(93)80655-e
Abstract
The sequence of the HIV Nef protein has no significant homology to other proteins in the SwissProt database, and experimental data concerning its function are sparse and contradictory. Using a novel protein sequence comparison method, we find similarities between different Nef sequences and the α chain of human MHC class I proteins. The possible biological implications of this finding are discussed.Keywords
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