Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
- 1 January 2003
- book chapter
- Published by Springer Nature
- Vol. 3, 53-63
- https://doi.org/10.1007/978-94-010-0263-9_6
Abstract
The appearance of the vertebrates demarcates some of the most far-reaching changes of structure and function seen during the evolution of the metazoans. These drastic changes of body plan and expansion of the central nervous system among other organs coincide with increased gene numbers. The presence of several groups of paralogous chromosomal regions in the human genome is a reflection of this increase. The simplest explanation for the existence of these paralogies would be two genome doublings with subsequent silencing of many genes. It is argued that gene localization data and the delineation of paralogous chromosomal regions give more reliable information about these types of events than dendrograms of gene families as gene relationships are often obscured by uneven replacement rates as well as other factors. Furthermore, the topographical relations of some paralogy groups are discussed. Key words conservation of chromosomal regions genome doubling paralogous chromosomal regions vertebrate evolutionKeywords
This publication has 49 references indexed in Scilit:
- Filling in the gapsNature, 2001
- The Genome Sequence of Drosophila melanogasterScience, 2000
- Multiple TGF‐β receptor related genes in sponge and ancient gene duplications before the parazoan–eumetazoan split1FEBS Letters, 1999
- Eukaryote genome duplication - where's the evidence?Current Opinion in Genetics & Development, 1998
- Counting on comparative mapsTrends in Genetics, 1998
- Paralogy Mapping: Identification of a Region in the Human MHC Triplicated onto Human Chromosomes 1 and 9 Allows the Prediction and Isolation of NovelPBXandNOTCHLociGenomics, 1996
- Evolution of gene families and relationship with organismal evolution: rapid divergence of tissue-specific genes in the early evolution of chordatesMolecular Biology and Evolution, 1996
- Mapping of the Syndecan Genes in the Mouse: Linkage with Members of the Myc Gene FamilyGenomics, 1994
- Comparative chromosome painting discloses homologous segments in distantly related mammalsNature Genetics, 1994
- Evolution of the Vertebrate Genome as Reflected in Paralogous Chromosomal Regions in Man and the House MouseGenomics, 1993