Growth of transplanted tails of infant rats in adolescent allogeneic recipients.

Publisher Website
Google Scholar
Abstract
The tails of newborn rats, consisting of slender continuous cones of avascular cartilate, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal C was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent differentiation into bone with bone marrow, and grew at a brisk rate. Acceptance was recognized by a zebra-stripe effect, visible in the gross, resulting from accumulation of C in reticuloendothelial cells; increase of alkaline phosphatase [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] and of incorporated 45Ca in the transplant; and the presence of dense cortical bone with lacunae populated with osteocytes demonstrable by histology. Differentiation of the cartilaginous transplant into bone with subsequent growth of the transplant occurred in recipients fed sucrose as their sole ration.