Development of multiple activities of UDP-glucuronyltransferase in human liver
- 1 May 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 243 (3) , 859-861
- https://doi.org/10.1042/bj2430859
Abstract
UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a ‘foetal’ form of UDP-glucuronyltransferase may exist in human liver that is more restricted in substrate specificity than are those of the rat or rhesus monkey.This publication has 21 references indexed in Scilit:
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