Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin

Publisher Website
Google Scholar
Abstract
OBJECTIVE There Is a cllnlcal need for population based reference values for serum Insulin-like growth factor I (IGF-I). We have therefore determined serum IGF-i concentrations In a random population sample from Sweden and have related the levels to age, sex, llfe style factors, blood pressure, body composition, blood llplds, plasma fibrlnogen, Parathyroid hormone (PTH) and osteocalcin. PATIENTS Wlthln the framework of the WHO MONICA Project In the city of Göteborg, Sweden, 197 men and 195 women aged 25–64 years were studied. RESULTS Women aged 25–34 years had higher IGF-I concentration than men (mean 278 vs 227 μg/l) but In the interval 55–64 years values were lower In women than In men (158 vs 171 μg/l). IGF-I correlated positively with height and inversely with age, body mass Index, systolic blood pressure and total cholesterol in both sexes. Negative relations between IGF-I and hlgh density llpoprotelncholesterol, as well as with amount of tobacco smoked, were found in men, and between IGF-I and diastolic blood pressure, triglycerldes and PTH in women. When age was allowed for in multivariate analyses, most of these relations disappeared. However, among men IGF-l was positively assoclated with flbrlnogen and negatively with age and smoking. IGF-I was negatively assoclated with age and coffee consumptlon in women. CONCLUSION The present data can be used as reference values for IGF-I (at least in Caucasians) for the diagnosis of growth hormone dlsturbances and as guidelines for growth hormone substitution.