Unusual anti-Selective Reduction of α-Methyl β-Alkylketo Esters by Organotin Hydride-Titanium Tetrachloride

1 September 1995

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1995 (09) , 965-966
https://doi.org/10.1055/s-1995-5136

Abstract

The highly stereoselective reduction of α-methyl β-keto esters is achieved by use of organotin hydride in the presence of titanium tetrachloride to give the anti β-hydroxy esters.

Keywords

KETO ESTER
REDUCTION
ORGANOTIN HYDRIDE
TITANIUM TETRACHLORIDE
STEREOSELECTIVITY

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