An asymmetric synthesis of ADDA and ADDA-glycine dipeptide using the β-lactam synthon method
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 559-568
- https://doi.org/10.1039/a809718f
Abstract
The paper describes the synthesis of the N-Boc lactam 4 and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-Glu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA·HCl and provided synthetic methods and full characterisation for the previously `elusive' free amino acid ADDA.Keywords
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