Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
Top Cited Papers
Open Access
- 1 July 2007
- journal article
- Published by American Society of Hematology in Blood
- Vol. 110 (1) , 278-286
- https://doi.org/10.1182/blood-2006-08-039883
Abstract
Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute lymphoblastic leukemia (T-ALL). Downstream pathways that transmitKeywords
This publication has 45 references indexed in Scilit:
- NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growthProceedings of the National Academy of Sciences, 2006
- Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-mycMolecular and Cellular Biology, 2006
- mTOR and cancer: insights into a complex relationshipNature Reviews Cancer, 2006
- c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaGenes & Development, 2006
- Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in miceProceedings of the National Academy of Sciences, 2006
- Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR ComplexScience, 2005
- Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisThe Journal of cell biology, 2004
- Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic LeukemiaScience, 2004
- Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences, 2001
- Notch Signaling: Cell Fate Control and Signal Integration in DevelopmentScience, 1999