Ontogeny of Adrenergic Arousal and Cholinergic Inhibitory Mechanisms in the Rat
- 31 October 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3905) , 635-637
- https://doi.org/10.1126/science.166.3905.635
Abstract
With spontaneous activity as a measure of arousal, dose response curves were established for scopolamine and amphetamine administered to 10-, 15-, 20-, 25-, and 100-day-old rats. Amphetamine always increased activity, but scopolamine had no efect on younger rats, which suggests that adrenergic excitatory areas in the brainstem mature more rapidly than cholinergic inhibitory areas in the forebrain.Keywords
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