A STUDY OF THE CENTRAL VASOMOTOR EFFECTS OF 2-DIMETHYL AMINOETHANOL (DEANOL)

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Abstract
Deanol produces many actions similar to acetylcholine to which it is structurally related. It produces a vasodepressor response in anesthetized dogs and has a muscarinic effect on guinea pig uterus and rabbit ileum. In contrast to acetylcholine, deanol produces distinct central effect in animals and humans on systemic administration. Deanol produces a fall in blood pressure peripherally. The drug was given by the [intracerebro-ventricular] route and like acetylcholine, deanol exerted a central vasomotor stimulant effect. On topical application it potentiated the pressor response obtained by direct electrical stimulation of the medullary vasomotor center. Deanol probably does not act through acetylcholine but has a direct stimulant action on the vasomotor center.

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