EFFECT OF RESERPINE ON THE HISTOCHEMISTRY AND CONTENT OF ADRENALINE AND NORADRENALINE IN THE ADRENAL MEDULLA OF THE RAT AND THE MOUSE

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Abstract
Male rats and mice were injected with 1–9 daily doses of reserpine. Adrenaline and noradrenaline contents of the adrenals were determined chemically,and their distributions histochemically, using the chromaffin reaction for both amines and the calcium-formol-induced fluorescence and the iodate reaction for noradrenaline. In the rat, a single reserpine injection of 0.25–0.5 mg. causes in 24 hours a selective, pronounced loss of noradrenaline from the specific medullary cell islets but does not influence the adrenaline content. The effect is abolished by denervation. Prolonged treatment causes a total loss of both amines. In the mouse, the contents of both adrenaline and noradrenaline decrease equally after a single injection of 1.0 mg. of reserpine, and a pronounced loss of both amines follows 4–6 daily injections of 0.1 mg. WIDE clinical use of reserpine has prompted several experimental investigations on this drug

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