Goldblatt,1in a series of historic experiments, showed that hypertension was induced in animals by constricting the renal arteries. Numerous investigators have confirmed and amplified these observations on various animals, and it is now universally admitted that lasting hypertension follows the experimental induction of partial renal ischemia. Goldblatt2later showed that hypertension also occurred following complete occlusion of one renal artery provided the renal vein was not obstructed. Taquini,3modifying the Goldblatt procedure, showed that a temporary rise in blood pressure occurred in dogs on the reestablishment of the circulation in kidneys rendered completely ischemic for a period of from four to six hours. Taquini's observations have been confirmed by us on cats, dogs, rats and guinea pigs,4although negative results were obtained in rabbits.5The mechanism responsible for the form of hypertension induced by the Taquini method has been the subject of extensive investigation.