Review of Toxicity of Oxyphenbutazone

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Abstract
A NEW antirheumatic agent, oxyphenbutazone (p-hydroxyphenylbutazone) synthesized by pfister and Häfliger,1 has been found to be identical with Metabolite I, discovered by Burns and associates 2 in the urine of patients receiving phenylbutazone. The chemical structure of oxyphenbutazone differs from that of phenylbutazone in the presence of a hydroxyl group on the para position of the benzene ring. Experimental pharmacologic studies in animals have demonstrated that oxyphenbutazone possesses the potency of phenylbutazone as an anti-inflammatory agent, but that it apparently does not have the tendency of the latter to produce serious side effects. Oxyphenbutazone has had several clinical trials in the treatment of various rheumatic conditions, including rheumatoid arthritis, and no serious side effects have so far been reported.2-6 Hart and Burley,3 who used oxyphenbutazone in 117 patients with rheumatic conditions, commented similarly on its low toxicity. Fourteen of their patients were observed for 3 to 12

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