Antibody-producing cells: virus-induced alteration of response to antigen.

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Abstract
Spleen antibody-forming cells of mice yield a 3- to 10-fold increase in their response to sheep erythrocyte antigen if they are acutely infected by lactate dehydrogenase-elevating virus. This early stimulation is replaced by a long-term inhibition of the antibody-forming cells as the viremia goes into its persisting chronic stage. These contrasting immunological phenomena are examined as contributing factors responsible for the enhancement by this virus of asparaginase (EC 3.5.1.1; L-asparagine amidohydrolase) therapy against leukemia in mice, and for the alteration of the susceptibility of mice to various neoplastic processes.