Nude mice are nonpermissive towards the anti‐dextran response of congenic cells

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Abstract
Nude mice bearing allotype Ighb on a BALB/c genetic background (= CB nu/nu) are nonresponders to α(1 → 3)dextran (Dex), in contrast to BALB/c or BALB/c nu/nu. Although CB nu/nu mice accept transplants of congenic BALB/c, or BALB nu/nu lymphocytes, as shown by the expression of donor allotype Igha, they are not permissive for a primary anti‐Dex response by the grafted cells. BALB/c or BALB nu/nu cells, however, give a strong anti‐Dex response when grafted onto irradiated CB nu/nu or CB23 (Ighb) euthymic mice.A thymus‐independent, radiation‐sensitive suppressor cell population is postulated, which specifically hinders the anti‐Dex response, and which is exhibited by strains bearing that portion of chromosome 12 which codes for CH allotype Ighb, not containing the germ‐line anti‐Dex V/D genes. The suppressive action of Ighb lymphocytes could be demonstrated directly in staggered co‐transfer experiments.