CHONDROITIN SULFATE CONCENTRATION AND PROTEIN-POLYSACCHARIDE COMPOSITION OF ARTICULAR CARTILAGE IN OSTEOARTHRITIS*
Open Access
- 1 June 1963
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 42 (6) , 853-859
- https://doi.org/10.1172/jci104777
Abstract
There is no decrease in chondroitin-sulfate concentration in normal cartilage with increasing age. A decreased chondroitin-sulfate concentration was found in osteoarthritic cartilage (more marked in the more severe lesions). Collagen concentrations remained unchanged. The polysaccharide content of the cartilage protein-polysaccharide complex was decreased in osteoarthritic lesions, but the protein concentration was unchanged. The biochemical findings suggest excessive breakdown of polysaccharide in osteoarthritic lesions, apparently due to a hyaluronidase-like enzyme.Keywords
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