THE EFFECTS OF SQUALENE ON THE INCORPORATION OF ACETATE INTO PLASMA CHOLESTEROL IN MAN 1

Abstract
The daily administration of 4% squalene for 5 days to 3 subjects who received sodium acetate-1-C14 in the middle of the feeding period resulted in a 2-to 23-fold depression in the synthesis of C14 plasma cholesterol from this 2-carbon fragment. The suppression of acetate incorporation by squalene feeding is probably the result of dilution of the higher intermediate pool between acetate and cholesterol.