A comparison of chemical and mechanical alterations of seizure patterns in mice.

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Abstract
Sound induced convulsive seizures may be reduced in some inbred strains of mice by pretreatment with glutamic acid or by interruption of an otherwise continuous sound stimulus. The effects of each of these and of the combination of the two procedures were studied in the normally susceptible DBA/1 strain at weaning age. Glutamic acid had a greater protective effect on males than on females. Where seizures occurred they were usually milder, and the affected animals were better able to survive the period of anoxia resulting from postconvulsive apnea. With interrupted stimulation, the incidence of seizure also was lowered, but no protection against anoxic deaths occurred, and no sex differences were observed. The combination of glutamic pretreatment with interrupted stimulation yielded results identical with glutamic pretreatment on continuous stimulation in males, but lowered the seizure risk in females by an amount numerically equal to the sum of the protective effects obtained by each of these means separately.

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