Pulmonary Metastases From Autochthonous 3-Methylcholanthrene-Induced Murine Tumors
- 1 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 63 (6) , 1393-1395
- https://doi.org/10.1093/jnci/63.6.1393
Abstract
In three experiments, 87%, 75%, and 85% of female C57BL/6N mice developed pulmonary metastases by 50 days after amputation of legs having autochthonous 3-methylcholanthrene-induced sarcomas. No difference in the incidence of pulmonary metastases was observed when autochthonous tumors of short (49–94 days) and longer (95–119 days) latency periods were compared. These metastasizing autochthonous tumors may provide a useful model for studies of metastases and for the evaluation of cancer therapy in a minimal residual disease setting.Keywords
This publication has 3 references indexed in Scilit:
- CANCER CHEMOTHERAPY MODEL USING AUTOCHTHONOUS LARGE BOWEL CANCER IN RATS1978
- Tumor immunity: Relevance of animal models to manHuman Pathology, 1977
- Biological Behavior Through Successive Transplant Generations of Transplantable Tumors Derived Originally From Primary Chemically Induced and Spontaneous Sources in MiceJNCI Journal of the National Cancer Institute, 1968