Antibiotic Concentrations in Human Bone
- 1 March 1974
- journal article
- Published by Wolters Kluwer Health in Journal of Bone and Joint Surgery
- Vol. 56 (2) , 305-310
- https://doi.org/10.2106/00004623-197456020-00008
Abstract
Fifty patients who underwent total hip arthroplasty were given oxacillin preoperatively and intraoperatively. Simultaneous specimens of bone and serum were obtained during the operation and assayed for oxacillin content. The different doses and modes of administration were compared with respect to antibiotic concentration in bone and in serum. Significant oxacillin bone levels were attainable when oxacillin was appropriately administered.Keywords
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