Prospective ke screening of potential carcinogens being tested in rodent bioassays by the US National Toxicology Program
- 1 March 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 7 (2) , 91-94
- https://doi.org/10.1093/mutage/7.2.91
Abstract
Values of ke, the rate constant of electron attachment, were measured in cyclohexane for 31 of 44 chemicals now being screened for carcinogenicity in rodent bioassays conducted by the US National Toxicology Program (NTP). These kes provide a physico-chemical measure of electron–solute interation in a non-polar medium which had been found to be correlated with solute carcinogenicity in our earlier studies of the keof chemical carcinogens and putative non-carcinogens. The ke test yields 15 negative and 16 positive responses for the 31 chemicals that were screended in this study. These ke results are compared with the predictions of other carcinogen-screening methods that have been applied to the same chemicals and also reported in this Discussion Forum.Keywords
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