RNA interference in adult mice
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- 4 July 2002
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 418 (6893) , 38-39
- https://doi.org/10.1038/418038a
Abstract
RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.Keywords
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