Terminal acute myelogenous leukemia in a patient with congenital agranulocytosis

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Abstract
Congenital agranulocytosis terminating in acute myelogenous leukemia has been previously reported in only two cases of adolescent males. We describe the clinical and laboratory features of a 13‐year‐old male with congenital agranulocytosis, treated with G‐CSF with initial good neutrophil response, who subsequently developed acute myeloid leukemia. This rare complication may define a preleukemic subset of patients for whom G‐CSF therapy is ineffective. The diagnostic challenges of this case are presented.