Albuterol and Isoproterenol Aerosols

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Abstract
Bronchodilator effect was objectively evaluated in ten patients with stable asthma, using spirometry and body plethysmography in a double-blind, double-cross-over study after 170μg of albuterol or isoproterenol sulfate was administered as an aerosol. Baseline values of the seven spirometric and plethysmographic indexes used were not significantly different before administration of the drugs. Initial bronchodilator response at 15 and 30 minutes was not significantly different, but peak response tended to be reached at about one hour after albuterol as opposed to 15 minutes for isoproterenol. Rate of fall of the indexes was roughly parallel after peak was reached. Duration of albuterol treatment was approximately four hours as opposed to two hours for isoproterenol treatment. These properties together with the previously reported minimal cardiovascular effects of albuterol justify extended therapeutic trials of this drug in the treatment of bronchial asthma.

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