Prognostic Parameters in Radiotherapeutic Management of Localized Carcinoma of the Prostate

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Abstract
A series of 215 patients with carcinoma of the prostate localized to the pelvis received radical radiotherapy. Treatment results were correlated with the tumor stage, tumor size defined independently from stage, doses of radiation and histological grade. The followup ranges from 2 to 13 yr (median 5 yr). Local recurrence was observed in 6.6% of stage B, 16.1% of stage C and 20% of stage D1 cases. Eighty percent of the patients with stage B disease, 56% with stage C and 0% with stage D1 survived 5 yr free of disease. Tumors less than 2 cm in diameter were controlled uniformly; tumors more than 2 cm in diameter showed an overall local control rate of about 85%. Increasing size resulted in a higher incidence of distant metastases. A dose of 6500 rad (180 to 200 rad/day) appears adequate for tumors less than 2 cm in diameter and stage B tumors; higher stage tumors required doses of 7000 rad (180 to 200 rad/day). Most high grade tumors and massive tumors of any grade fail outside the pelvis.