The Relation of Water, Sodium, and Potassium Distribution to Work Performance in Old Rats

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Abstract
Studies of the rat gastrocnemius stimulated in situ have shown that the performance of work is associated with a progressive fall in the transmembrane concentration gradients of both sodium and potassium. In most of the old rats examined, the sodium concentration gradient was depressed even at rest while the potassium gradient was maintained at a near normal level. In these rats the ability to perform work was markedly diminished. In the remainder of the old rats the potassium gradient was depressed in association with an even steeper fall in the sodium gradient. These rats were almost entirely unable to perform work.

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