14-Methyl steroids. Part 2. Total synthesis of (±)-14α-methyl-19-norsteroids
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2723-2727
- https://doi.org/10.1039/p19830002723
Abstract
trans-1,6-Dimethylbicyclo[4.3.0]nonane-2,7-dione (1) is converted, via regiospecific homologation at C-2, into trans-1,6-dimethyl-2-methylenebicyclo[4.3.0]nonane-3,7-dione (6). Conjugate alkylation of (6) with m-methoxybenzylmagnesium chloride followed by acid treatment, affords a mixture of (±)-3-methoxy-14-methyl-14α-estra-1,3,5(10),9(11)-tetraen-17-one (8) and the corresponding Δ8-isomer (9). The stereoselectivity of reductions of the Δ9(11)- and Δ8-bonds in (8) and (9) and the derived 17-acetals is examined, and an efficient synthesis of (±)-3-methoxy-14-methyl-14α-estra-1,3,5(10)-trien-17-one (13) is described.Keywords
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