Studies in detoxication

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Abstract
For doses from 100-250 mgm./kgm. the % of phenol conjugated with sulphate was 20%. For doses lower than 100 mgm./ kgm. (down to 25 mgm./kgm.), the % conjugated rose with falling dose. In mono-substituted phenols, the extent of the sulphate conjugation depended on the nature and position of the substituent. Acidic o-substituents lowered, and basic o-substituents increased the conjugation by 50%. Neutral o-groups had no effect. In the [image]-position similar effects to the o-position prevailed, but were less pronounced. p-Substitution had little effect on the conjugation. The possible influence of the ortho-effect, in the detoxication of o-substituents, was discussed.

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