THE EFFECTS OF ANTIDIURETIC HORMONE ON URINE FLOW AND COMPOSITION IN THE CHRONICALLY-CANNULATED OVINE FETUS
- 10 October 1978
- journal article
- research article
- Published by Wiley in Quarterly Journal of Experimental Physiology and Cognate Medical Sciences
- Vol. 63 (4) , 315-330
- https://doi.org/10.1113/expphysiol.1978.sp002445
Abstract
The fetuses of 9 pregnant ewes were chronically cannulated between 86 and 130 days with cannulae in 1 carotid artery, 1 jugular vein, the fetal bladder and the amniotic cavity. The effects of infused AVP [arginine vasopressin] on fetal urine flow rate and composition were studied. A dose of 35 pmol/h always caused an increase in urine osmolality and a decrease in flow rate and free water clearance without change in blood pressure. Higher doses (140 pmol/h) were significantly pressor and caused increased excretion of Na, Cl, urea and creatinine. Although this dose always caused an increase in urine osmolality, in 5 experiments the flow rate also rose. The ovine fetus apparently has the ability to control its own urine flow and composition, and possibly also amniotic fluid volume and composition.This publication has 1 reference indexed in Scilit:
- Effects of steady‐state plasma vasopressin levels on the distribution of intrarenal blood flow on electrolyte excretion.The Journal of Physiology, 1977