An immunochemical approach for the determination of trace amounts of enantiomeric impurities
- 2 August 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 17,p. 1581-1582
- https://doi.org/10.1039/b004587j
Abstract
The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100000 fold excess of the L-enantiomer (ee 99.998%).Keywords
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