Postoperative radiation therapy after radical prostatectomy for prostate carcinoma

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Abstract
Results. At 10 years, the actuarial local failure rate was 31% for patients treated with prostatectomy alone versus 6% for the group receiving postoperative radiation therapy (P < 0.05). The actuarial survival and metastasis‐free survival were similar for both groups. When patients with involved lymph nodes were excluded from analysis, the addition of radiation therapy resulted in improved recurrence‐free survival (91% versus 46% at 10 years, P = 0.04) and in a trend toward improved metastasis‐free survival (91% versus 55%, P = 0.08). Complications occurred in similar frequencies in both groups. Conclusions. In patients with local disease extension or positive surgical margins after radical prostatectomy, adjuvant radiation therapy improved local control and was administered with acceptable side effects. Cancer 1992; 70:1960–1966.

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