Relationship of the Genetic Determination of Impaired Penicillin Production in Naturally Occurring Strains to that in Induced Mutants of Aspergillus nidulans

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Abstract
The relationship of the genetic determination of impaired penicillin production in natural isolates of A. nidulans to the npe mutations induced in A. nidulans NRLL194, which were used in work on the genetics of the biosynthesis and overproduction of penicillin, was examined. Allelism tests between natural isolates and laboratory mutants impaired in penicillin yield suggest that the failure of certain wild-type strains to produce the antibiotic was due to their carrying a spontaneous mutation at the npeA locus. The frequent occurrence of mutation at this locus among wild-type and mutagen-treated strains indicates that this gene probably plays an important role in penicillin biosynthesis.

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