S-Adenosylmethionine Synthetase Isozymes in the Liver of Tumor-Bearing Mice1

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Abstract
Isozyme patterns of S-adenosylmethionine synthetase were determined with and without dimethylsulfoxide in livers of tumor-bearing mice. The activity of the .beta.-form markedly increased following i.p. transplantation of Ehrlich ascites tumor cells whereas the activity of the .alpha.-form did not change so strikingly. Tumor cells were shown to have only the .gamma.-form of the enzyme. When the ascites fluid was injected into a normal mouse after removal of tumor cells, the activity of the .beta.-form increased over that of control animals.

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