Experiences with malaria chemoprophylaxis

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Abstract
Hungarian citizens travelling to malaria endemic regions have been supplied with malaria chemoprophylactics since the compulsory screening examinations initiated in 1962. Upon return to Hungary after long-term service an additional screening examination is performed. In this present study we report information gained from examination of 15 600 persons. From our examinations we found that chemoprophylactics given by our Institute (chloroquine, pyrimethamine) and taken regularly by our patients provide sufficient protection against manifest disease. The data from 12 780 persons show that with regular chemoprophylaxis the occurrence of malaria was one-tenth of that in persons not taking the drug (1·2% compared with 12%).