Glioblastoma Multiforme and the Epidermal Growth Factor Receptor

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Abstract
Glioblastoma multiforme is one of the most aggressive and recalcitrant cancers. A tumor that can be identified radiographically can sometimes be resected, yielding a putatively clean magnetic resonance image postoperatively, but tumor cells are invariably present in areas of the brain that are at a considerable distance from the site of initial diagnosis. The delivery of radiotherapy to a field encompassing the tumor and a margin of 2 to 3 cm increases survival, but not substantially. Systemic treatment may be beneficial, but therapy with nitrosoureas and the methylating agent temozolomide increases survival only slightly. Virtually all patients with glioblastoma multiforme . . .

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