SIGNIFICANCE OF MIXED LEUKOCYTE CULTURE TESTING IN CADAVER KIDNEY TRANSPLANTATION

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Abstract
A significant correlation of kidney transplant outcome with the strength of mixed leukocyte culture stimulation was found in a series of 131 cadaver donor transplants. Graft survival rates in patients whose cultures with donor cells resulted in 20,000 cpm (at 6 months and 1 year P < 0.001). Cultures of recipient with normal control lymphocytes also correlated with clinical outcome, albeit to a somewhat lesser degree. Bidirectional cultures gave a slightly better correlation than unidirectional cultures. Whether the patient's plasma contained factors that blocked the mixed leukocyte culture reaction or not was not found to have a significant effect on transplant outcome.