Approaches to identify, clone, and express symbiont bioactive metabolite genes
- 15 December 2003
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Natural Product Reports
- Vol. 21 (1) , 122-142
- https://doi.org/10.1039/b302336m
Abstract
Covering: 1981–2003 This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.This publication has 37 references indexed in Scilit:
- New approaches to analyzing microbial biodiversity dataCurrent Opinion in Microbiology, 2003
- Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilisNature Biotechnology, 2003
- A genomics-guided approach for discovering and expressing cryptic metabolic pathwaysNature Biotechnology, 2003
- Ultrastructural, biochemical, and immunological characterization of two populations of the mytilid mussel Bathymodiolus azoricus from the Mid-Atlantic Ridge: evidence for a dual symbiosisMarine Biology, 2002
- The Practical Synthesis of a Novel and Highly Potent Analogue of BryostatinJournal of the American Chemical Society, 2002
- Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidiaNature Genetics, 2002
- Unravelling host and symbiont phylogenies of halichondrid sponges (Demospongiae, Porifera) using a mitochondrial markerMarine Biology, 2002
- Localization Studies of Bioactive Cyclic Peptides in the Ascidian Lissoclinum patellaJournal of Natural Products, 2002
- Marine natural productsNatural Product Reports, 2001
- Novel Natural Products from Soil DNA Libraries in a Streptomycete HostOrganic Letters, 2000