EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASE
- 1 April 1943
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 71 (4) , 483-488
- https://doi.org/10.1001/archinte.1943.00210040042005
Abstract
Protoporphyrin III constitutes the prosthetic group of certain vital substances, notably hemoglobin.1Only porphyrins of isomeric series I and III occur naturally in plants and animals, and Fischer2pointed, out that it is inconceivable for porphyrins of types I and III to be transformed one to the other in any biologic process, that they must be formed individually in the physiologic synthesis. Porphyrin arises in the body during synthesis of hemoglobin rather than during its destruction, as had been supposed formerly, a small proportion of isomeric series I arising as a by-product of the main synthesis of isomeric series III intended for utilization in the manufacture of hemoglobin.3The porphyrin of isomeric series I is not utilized and is excreted as coproporphyrin I, and any porphyrin of isomeric series III which has been synthesized in greater amounts than are necessary to meet the immediate requirements, or whichThis publication has 7 references indexed in Scilit:
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- EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASEArchives of internal medicine (1960), 1942
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