Effect of Arotinolol on Hemodynamics and Plasma Atrial Natriuretic Peptide at Rest and During Stress in Spontaneously Hypertensive Rats

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Abstract
We investigated the effects of chronic treatment with arotinolol, a β-blocker with weak α-blocking potency, on hemodynamics and plasma levels of catecholamines and atrial natriuretic peptide (ANP) at rest and during stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. At rest, arotinolol treatment decreased mean arterial pressure (MAP), cardiac index (CI) and heart rate (HR), with no changes in total peripheral resistance index or regional hemodynamics in SHR. Acute stress caused more remarkable hemodynamic changes in SHR. During stress, arotinolol decreased MAP, CI and HR, and reduced myaoardial and skeletal muscle flow and splanchnic, renal, cerebral and