Sodium Novobiocin: Stability Aspects

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Abstract
The stability of monosodium novobiocin has been examined. The solid antibiotic has been shown to be sensitive to light, but if properly protected, to be stable for a period of 2 years at 20°. In aqueous solution and suspension it is affected by increase of temperature, pH and certain heavy metals. Phosphate, and possibly sulphate, also cause decomposition. Concentrated solutions of novobiocin become coloured, particularly above 20° and in the presence of air. Light has little effect on potency but irradiation with ultra-violet light accelerates potency loss in solution. There appears to be no difference in the potency stability of three different batches of sodium novobiocin. Ultra-violet spectrophotometry cannot be used as a method of assay.

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