Three new long-acting converting-enzyme inhibitors: Relationship between plasma converting-enzyme activity and response to angiotensin I

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Abstract
Three new angiotensin converting-enzyme [CE] inhibitors [1-carboxyethyl-3-phenyl]propylalanylproline, MK-421; MK-421 diacid and MK-421 analog] were given orally to 20 men in single doses ranging from 1.25-40 mg. Two of the drugs induced comparable marked inhibition of both the blood pressure response to exogenous angiotensin [A] I and plasma CE activity. Onset of action was relatively slow, but 21-24 h after drug plasma CE activity was still clearly reduced. The 3rd was less active. There was a close correlation between blood pressure response on administration of AI and plasma CE activity. There were no adverse effects. These new drugs are interesting due to their long duration of action. The measurement of plasma CE activity seems useful for monitoring efficacy of CE blockade and compliance to therapy.